5-Hydroxymethylcytosine
cfDNA-derived 5hmC signals are interpreted as a composite of tumor-derived and host-biology processes. 5hmC is described as an epigenetic mark enriched in actively transcribed genomic regions. 5hmC-Seal sequencing enables genome-wide 5hmC…
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cfDNA-derived 5hmC signals are interpreted as a composite of tumor-derived and host-biology processes. 5hmC is described as an epigenetic mark enriched in actively transcribed genomic regions. 5hmC-Seal sequencing enables genome-wide 5hmC quantification from circulating cell-free DNA. The study measured genome-wide 5hmC levels at 19,100 gene body regions and retained 14,147 genes after quality control.