Age Acceleration

RelAge-GNN showed stronger disease age-acceleration sensitivity than the baselines in the reported analyses. For postmenopausal ovarian cancer, RelAge-GNN identified about 40% of disease samples as having positive age acceleration. In schizophrenia, the three compared models had similar age-acceleration performance. Age acceleration is defined as predicted age minus chronological age. Age acceleration means biological or phenotypic ageing appears more advanced than expected for chronological age. Behavioural determinants of health include modifiable factors such as sleep, physical activity, perceived stress, and diet. Ageing phenotypes are observed across cognitive, psychological, physical, and functional domains. Cancer and cancer treatments are presented as potential contributors to accelerated ageing through chromosomal, telomeric, and phenotypic changes. In survivors, accelerated ageing may appear as comorbid conditions and functional decline. Disease analyses evaluate whether disease samples have positive age acceleration and whether positive age acceleration identifies disease cases. Age acceleration is interpreted as more biologically informative than ordinary regression er…