Aging and Disease

Stress-induced translational regulation is framed as a determinant of homeostasis, proteostasis, disease vulnerability, and aging. Reduced translation is presented as capable of extending lifespan across multiple model organisms. Further work is needed to determine when translational repression is protective, when selective translation is required, and how modulation can avoid impairing essential protein synthesis. ISRIB is cited as a pharmacological intervention that activates eIF2B, reverses effects of eIF2α phosphorylation, dissolves stress granules, and restores translation in cited studies. Therapeutic relevance is suggested for dysregulated protein synthesis, cancer, neurodegeneration, stress maladaptation, and age-related decline.