Alzheimer's Disease Progression
The ADNI sequence was not the classic amyloid-to-CSF tau-to-MRI-to-cognition ordering. Early entorhinal and medial temporal abnormalities align with Braak staging and structural MRI progression. The ADNI progression is interpreted as broad…
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The ADNI sequence was not the classic amyloid-to-CSF tau-to-MRI-to-cognition ordering. Early entorhinal and medial temporal abnormalities align with Braak staging and structural MRI progression. The ADNI progression is interpreted as broadly consistent with a neurodegeneration-first model of late-onset Alzheimer's disease. The ADNI-derived ordering should not be treated as a definitive biological Alzheimer's timeline.