Anatomical Prior Knowledge

The article concludes that anatomical prior knowledge in preprocessing can improve biological plausibility without dimensionality reduction or loss of accuracy. The whitening pairs were chosen from prior anatomical assumptions rather than learned or exhaustively optimized. The selected pairwise whitening approach explicitly incorporates anatomical prior knowledge. Left-right correlations were only partially whitened because inter-hemispheric relationships might contain class-relevant information. GM-CSF inverse relationships were fully whitened because they were treated as stable anatomical or statistical dependencies.