Antiemetic Therapy
Guidelines for highly emetogenic chemotherapy recommend standard combinations of three or four drugs including dexamethasone, a 5-HT3 receptor antagonist, an NK1 receptor antagonist, and sometimes olanzapine. Despite four-drug antiemetic c…
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Guidelines for highly emetogenic chemotherapy recommend standard combinations of three or four drugs including dexamethasone, a 5-HT3 receptor antagonist, an NK1 receptor antagonist, and sometimes olanzapine. Despite four-drug antiemetic combinations, nausea control remains limited. Olanzapine use is at the treating physician's discretion and will be included as a covariate to account for potential confounding. Dexamethasone is permitted for enrolled participants because it is necessary for anticancer drugs with high emetogenic risk.