Antioxidant Defense Genes

The antioxidant genes are interrelated, and a mutation in one increases the burden on the others. When multiple antioxidant enzyme variants are present, the article recommends liver detoxification support before antioxidant supplementation. GPX1 risk alleles are linked to lower baseline antioxidant protection and greater selenium requirement. SOD2 variants are associated with heightened sensitivity to glyphosate, fluoridated water, chronic stress, poor sleep, and shallow breathing. CAT variant carriers are described as having increased BPA and plastics sensitivity and elevated DNA damage risk.