APOL1-Associated Kidney Disease Mechanisms

In vivo evidence shows that cell-specific expression of APOL1 high-risk variants causes hypertension and renal injury. APOL1 risk variant expression drives kidney damage by inducing vascular dysfunction and cellular stress. Expression of APOL1 risk variants drives kidney damage by inducing vascular dysfunction and cellular stress. The kidney damage pathway in APOL1 high-risk variants is linked to systemic vascular effects. The APOL1 kidney damage pathway is linked to systemic vascular effects. In vivo evidence indicates that cell-specific expression of APOL1 high-risk variants causes both hypertension and renal injury. The kidney damage pathway is linked to systemic vascular effects.