Atherosclerotic Cardiovascular Disease

ASCVD patients in the cohort tended to be older and had more adverse baseline clinical features than patients without ASCVD. ASCVD was defined as myocardial infarction, ischaemic stroke, or prior coronary stent implantation. ASCVD was the primary outcome and included stroke, fatal coronary heart disease, and non-fatal myocardial infarction. ASCVD was identified through coronary artery disease, peripheral artery disease, or stroke diagnosis codes. Sepsis can worsen ASCVD-related cardiovascular complications by accelerating endothelial dysfunction and atherothrombosis. After adjustment for traditional cardiovascular risk factors, a 1-SD increase in loge(cfPWV) was associated with 21% higher ASCVD risk. For a reference individual, each 1 m/s higher cfPWV corresponded to a 7.4% higher ASCVD risk. Pre-existing ASCVD adds vascular and hemodynamic risk for ICU patients with sepsis. ASCVD was described as a major contributor to mortality worldwide and in China.