Attractors
The epithelial attractor corresponds to an epithelial proliferative state with ESE-2, NF-kB, E2F, and Cyclin activity. The senescent attractor corresponds to epithelial senescence with cell-cycle repression. The mesenchymal stem-like attra…
1 sources - 5 claims
The epithelial attractor corresponds to an epithelial proliferative state with ESE-2, NF-kB, E2F, and Cyclin activity. The senescent attractor corresponds to epithelial senescence with cell-cycle repression. The mesenchymal stem-like attractor corresponds to a proliferative EMT-derived state with immortalization features. The attractor structure was robust to random perturbations of logical rules. Stable cell phenotypes are treated as attractors in the regulatory network.