B Cells
Anti-CD20 B-cell depletion often produces only partial and transient responses because long-lived plasma cells lack CD20. B cells contribute to autoimmune disease by producing autoantibodies, presenting antigens, and secreting inflammatory…
1 sources - 4 claims
Anti-CD20 B-cell depletion often produces only partial and transient responses because long-lived plasma cells lack CD20. B cells contribute to autoimmune disease by producing autoantibodies, presenting antigens, and secreting inflammatory cytokines. Long-lived plasma cells can maintain pathogenic autoantibody levels indefinitely. Regulatory B-cell loss or dysfunction removes a restraint on immune activation.