Bartonella Testing

Combining real-time PCR with IFA is said to improve detection accuracy for B. henselae compared with either test alone. Bartonella testing is divided into direct organism detection and indirect antibody detection. Bartonella often requires multiple tests before a positive result is obtained. Bartonella serology is described as poor for detecting past or chronic infection. Some patients do not produce enough circulating antibodies for antibody-based Bartonella tests to become positive. Antibody tests should be delayed at least four weeks after suspected tick bite exposure. Direct testing such as PCR or FISH is presented as necessary when antibody-based testing fails due to insufficient antibodies. IGXSpot is preferred for suspected early infection before antibodies have developed.