Benzodiazepines

Compared with oral lavender oil, benzodiazepines act faster but have a more problematic long-term adaptation profile. Clinical guidelines recommend limiting benzodiazepine use to 4 weeks for insomnia and 12 weeks for anxiety. Combining benzodiazepines with alcohol, also a CNS depressant, produces additive or synergistic nervous system depression. Benzodiazepines, including diazepam, alprazolam, and clonazepam, are central nervous system depressants. Benzodiazepines rapidly relieve anxiety by strongly enhancing GABA receptor signaling. The benzodiazepine–alcohol combination can cause dangerously low blood pressure, suppressed respiration, reduced heart rate, and potentially fatal outcomes. Prolonged benzodiazepine use in older adults is associated with falls, fractures, cognitive impairment, memory impairment, and physical dependence. Benzodiazepines can lead to tolerance because the brain adapts by reducing its own GABA sensitivity. Benzodiazepines are associated with dependence and cognitive side effects. Deprescribing benzodiazepine receptor agonists is recommended for all adults aged 65 or older.