Bioelectronic Medicine

Implantable vagal nerve stimulators developed by SetPoint Medical have shown effectiveness in modulating inflammatory markers and improving outcomes in rheumatoid arthritis. Bioelectronic medicine is founded on the discovery that the brain regulates peripheral immune activity via a neural circuit called the inflammatory reflex, conducted primarily through the vagus nerve. Electrical stimulation of the vagus nerve can suppress systemic inflammation. The inflammatory reflex has implications extending beyond pain, connecting to cardiovascular disease, rheumatoid arthritis, and metabolic disorders.