Biomarkers and Assessments
A composite chemokine marker using circulating CCL20 and CXCL11 will be validated against clinical outcomes and liver biopsy assessment. The optional biopsy sub-study directly assesses OCA effects on bile duct injury and cellular senescenc…
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A composite chemokine marker using circulating CCL20 and CXCL11 will be validated against clinical outcomes and liver biopsy assessment. The optional biopsy sub-study directly assesses OCA effects on bile duct injury and cellular senescence. OPERA explores mechanistic biomarkers related to biliary epithelial cell senescence. Transient elastography is used as a non-invasive surrogate marker of liver fibrosis.