Blood-Brain Barrier

The more precise question is how efficiently and quickly different magnesium forms can raise brain magnesium in specific conditions. Magnesium itself crosses the blood-brain barrier and is normally present and regulated in the brain. Damage to the blood-brain barrier is one of the conditions associated with elevated S100B levels. Magnesium entry into the brain is not determined simply by the supplement form named on a bottle. The blood-brain barrier is a regulated system rather than a simple wall that only special supplement forms can cross. A useful neurodegenerative therapy must affect brain outcomes despite the delivery challenge posed by the blood-brain barrier. The article frames neurodegenerative disease partly as disrupted signaling and network function, not only cell death. The blood-brain barrier is a major obstacle for therapies aimed at neurodegenerative disease.