Bradykinin Pathway
The vasodilator molecules induced by bradykinin signalling relax vascular smooth muscle, producing vasodilation and blood pressure reduction. B2 receptor activation may reduce inflammation, increase antioxidant defenses, and improve insuli…
1 sources - 5 claims
The vasodilator molecules induced by bradykinin signalling relax vascular smooth muscle, producing vasodilation and blood pressure reduction. B2 receptor activation may reduce inflammation, increase antioxidant defenses, and improve insulin sensitivity. KLK1 cleaves kininogen to release bradykinin. Bradykinin binds the B2 receptor on endothelial cells and upregulates nitric oxide, prostacyclin, and endothelium-derived hyperpolarising factor. Bradykinin/B2 receptor signalling may bypass the sFlt-1 block central to pre-eclampsia pathogenesis by restoring VEGFR2 activity.