C. elegans

Urolithin A extended lifespan in C. elegans by about 50%. Lifespan extension results observed in C. elegans do not translate directly to humans. The lifespan increase in C. elegans was considered large because few compounds produce comparable effects in worms. A 50% lifespan extension in C. elegans is described as unusually large because few interventions achieve that magnitude. The organism-level effect of urolithin A was demonstrated in C. elegans after cellular-level mitochondrial effects were observed. C. elegans is a worm commonly used in aging and lifespan research.