CAPTURE Study

CAPTURE's principal strengths include geographic diversity, dual blinded expert CXR reads, a wide range of CAD products evaluated, and acceptance of multiple image formats including from analogue X-ray machines. CAPTURE is coordinated by FIND, Stellenbosch University, and the University of California San Francisco. A key limitation of CAPTURE is the variability in data completeness and the challenge of harmonising clinical variables across contributing studies with different original designs. Approximately 20 qualifying studies were identified through a systematic review of TB diagnostic studies from 2012 to 2022, representing a potential pool of up to 11,000 CXRs. The held-out CAPTURE validation set is one-third of the repository, selected to be representative across age, sex, TB disease spectrum, geographic origin, HIV status, and nutritional status.