Carbapenem-Resistant Gram-Negative Bacilli

CRE had the lowest detection rate among detected surveillance organisms but showed the most concerning upward trend over time. Total detected CRE strains had the steepest upward trend of all organisms in the linear regression analysis. Optimal antibiotic treatment options for CRE infections remain uncertain and limited. The 2008 detection of NDM-1 provides the rationale for beginning the review search window on 1 January 2009. CRE primarily spreads through contact transmission and may cause either infection or asymptomatic colonisation. Carbapenem resistance can arise through carbapenemase enzyme production. CRGNB infections are associated with high morbidity, longer hospital stays, elevated mortality, and rising incidence and prevalence. CRE infections have high attributable mortality according to a 2021 systematic review cited by the article. Carbapenem-resistant Gram-negative bacilli are a critical subset of multidrug-resistant organisms that create growing health and economic burdens worldwide.