CaV1.2 / CACNA1C
Whether CACNA1C risk variants produce gain-of-function or loss-of-function effects remains uncertain, making the direction of therapeutic intervention unclear. CACNA1C SNPs have been identified in genome-wide association studies spanning s…
1 sources - 4 claims
Whether CACNA1C risk variants produce gain-of-function or loss-of-function effects remains uncertain, making the direction of therapeutic intervention unclear. CACNA1C SNPs have been identified in genome-wide association studies spanning schizophrenia, bipolar disorder, major depression, ADHD, and autism. CaV1.2 is encoded by the CACNA1C gene and mediates calcium signalling in neurons. CaV1.2 contributes to neuronal survival, dendritic development, synaptic plasticity, learning, memory, and behaviour.