CBT-Fatigue

Individual CBT-Fatigue had a 63% probability of being cost-effective versus usual care. CBT-Fatigue yielded an estimated QALY gain of 0.045, lower than mindfulness and physical activity promotion. Group CBT-Fatigue had an expected probabilistic intervention cost of £485. Individual CBT-Fatigue had an expected probabilistic intervention cost of £810. Individual CBT-Fatigue was the most expensive intervention because it required more staff contact time in frequency and session duration. CBT-Fatigue had the largest evidence base across follow-up points and was the only intervention with long-term data from multiple condition types. Individual CBT-Fatigue became not cost-effective under several pessimistic or higher-cost scenario assumptions. CBT-Fatigue was one of the three intervention categories included in the model.