CD19
Anti-CD19 CAR T cells deplete B cells in peripheral blood and deep tissue compartments. CD19 CAR T selectively suppresses the type I interferon gene signature in SLE. CD19 is broadly expressed across B-lineage development but not on fully…
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Anti-CD19 CAR T cells deplete B cells in peripheral blood and deep tissue compartments. CD19 CAR T selectively suppresses the type I interferon gene signature in SLE. CD19 is broadly expressed across B-lineage development but not on fully differentiated long-lived plasma cells. CD19-targeted allogeneic CAR T was applied to severe myositis and systemic sclerosis.