CD38
CD38 is extraordinarily metabolically expensive, requiring 100 NAD molecules to produce a single downstream signaling molecule. CD38 upregulation is driven by cellular senescence through pro-inflammatory SASP signaling. CD38 and cellular s…
1 sources - 4 claims
CD38 is extraordinarily metabolically expensive, requiring 100 NAD molecules to produce a single downstream signaling molecule. CD38 upregulation is driven by cellular senescence through pro-inflammatory SASP signaling. CD38 and cellular senescence form a self-reinforcing cycle that accelerates NAD depletion by impairing the repair systems that would otherwise clear senescent cells. Aging increases DNA repair demand at precisely the moment NAD availability is lowest, compounding the deficit.