Cerebral Amyloid Angiopathy
Most CAA cases worldwide are sporadic. Dutch-type hereditary CAA is caused by a mutation at codon 693 of the amyloid precursor protein gene on chromosome 21. CAA involves amyloid-beta deposits in leptomeningeal arteries, cortical arteriole…
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Most CAA cases worldwide are sporadic. Dutch-type hereditary CAA is caused by a mutation at codon 693 of the amyloid precursor protein gene on chromosome 21. CAA involves amyloid-beta deposits in leptomeningeal arteries, cortical arterioles, and capillaries. Cerebral amyloid angiopathy is a major cause of intracerebral haemorrhage, cognitive dysfunction, and dementia in older adults. About 60% of lobar intracerebral haemorrhages are attributed to CAA. No curative or disease-slowing treatment currently exists for CAA.