Circadian Insulin Sensitivity

A morning meal may produce substantially lower blood glucose than an identical late-afternoon meal. The same glucose load can require less insulin in the morning than later in the day. Later eating relative to an internal clock was associated with lower insulin sensitivity independent of calorie intake. Insulin sensitivity varies by time of day and is higher in the morning. Insulin sensitivity is highest in the morning and lowest in the evening. Evening muscle biology is more oriented toward fat creation and storage than morning muscle biology. Morning glucose tolerance is better partly because insulin secretion and skeletal muscle insulin sensitivity are greater.