Citrate Accumulation
Most calcium-citrate complexes are removed in effluent, while a smaller fraction enters systemic circulation. Systemic citrate is metabolised mainly in the liver, muscles, and renal cortex into bicarbonate. Impaired citrate metabolism can…
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Most calcium-citrate complexes are removed in effluent, while a smaller fraction enters systemic circulation. Systemic citrate is metabolised mainly in the liver, muscles, and renal cortex into bicarbonate. Impaired citrate metabolism can lead to citrate accumulation, especially with severe liver dysfunction or hypoperfusion. Citrate accumulation may limit safe RCA use and worsen prognosis.