Clear-Brain Trial
The study plans to include 60 participants split between sporadic CAA and Dutch-type hereditary CAA. Recruitment began with the first participant enrolled on 27 March 2025. The Clear-Brain study is a single-centre randomised pre-post clini…
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The study plans to include 60 participants split between sporadic CAA and Dutch-type hereditary CAA. Recruitment began with the first participant enrolled on 27 March 2025. The Clear-Brain study is a single-centre randomised pre-post clinical trial at Leiden University Medical Center. The intervention phase follows a 3-month observational phase in a 6-month pre-post design. The trial tests whether low-sodium oxybate, non-invasive vagus nerve stimulation, or both can improve amyloid-beta clearance in cerebral amyloid angiopathy. Participants are allocated to low-sodium oxybate, non-invasive vagus nerve stimulation, or a combination of both interventions.