Clinical Outcomes

LNG-IUS produced a greater reduction in spotting days than HNR at 6 months. Thirteen of the fifteen studies reported significant improvement in depressive symptoms. Valve intervention was associated with higher survival and fewer adverse cardiovascular outcomes. Higher exercise treatment belief and lower baseline anxiety and depression were associated with greater disability reductions. The central clinical question is whether an 8-week combined electrotherapy and cervical exercise programme reduces disability and pain. The mean ODI improvement was 6.20 points, at the lower end of the debated MCID range. HbA1c fell by 0.97 percentage points at 6 months, a change that would usually be clinically significant. Lower pain rumination and helplessness were associated with greater pain reductions. All measured health outcomes improved at 6 months. Nine of the thirteen studies with improved depressive symptoms also reported significant improvement in hypertension control. Hybrid DCB was associated with a lower composite endpoint risk than side-branch balloon angioplasty in pooled analysis. Hybrid DCB was associated with a lower composite endpoint risk than two-stent treatment in pooled an…