Clinical Testing

The article says a B complex is insufficient when B12 is severely low and targeted high-dose B12 should come first. Homocysteine should be retested within 60 days after supplementation begins. The DNA methylation profile uses a buccal swab to assess SNPs involved in methyl group production and recycling. A neurobasic profile measures serotonin, dopamine, norepinephrine, and epinephrine without metabolites. A comprehensive neurotransmitter profile adds metabolites to assess synthesis and clearance. The article argues that homocysteine should be ordered for every patient with a mental health complaint. A B complex may be appropriate when multiple deficiencies are present or no single cause is identified. The article recommends combining three tests to assess genetic predisposition, metabolic function, and neurotransmitter output. The recommended initial test panel includes homocysteine, B12, CBC, MMA, and MTHFR C677T genotyping. Using all three tests is presented as a way to target nutrient support instead of adding another medication.