Cloxacillin
Treatment follows standard care and usually uses intravenous cloxacillin 2 g every 6 to 8 hours for at least 7 days. The trial measures both total and unbound cloxacillin concentrations at steady state on days 2 and 7. Cloxacillin is highl…
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Treatment follows standard care and usually uses intravenous cloxacillin 2 g every 6 to 8 hours for at least 7 days. The trial measures both total and unbound cloxacillin concentrations at steady state on days 2 and 7. Cloxacillin is highly protein bound, which can make total concentrations an unreliable proxy for active drug exposure. Cloxacillin is considered first-line therapy for methicillin-susceptible Staphylococcus aureus bacteraemia in Sweden.