Coagulation and Immune-Thrombosis Mechanisms
Cochrane evidence associates peripheral nerve block with shorter time to first postoperative mobilization, which may help reduce DVT risk. Adequate analgesia is being tested as a way to reduce hypercoagulability and immobility, not only as…
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Cochrane evidence associates peripheral nerve block with shorter time to first postoperative mobilization, which may help reduce DVT risk. Adequate analgesia is being tested as a way to reduce hypercoagulability and immobility, not only as pain control. Preoperative hip-fracture pain can intensify systemic inflammatory and stress responses, promoting thrombosis through tissue factor activation and neutrophil extracellular trap formation. MPO-DNA complexes and citrullinated histone H3 are quantified using ELISA kits, while other biomarkers are analyzed by the hospital central laboratory. The trial measures immune-thrombosis biomarkers including MPO-DNA complex and citrullinated histone H3 as secondary outcomes.