Coimbra Protocol

Observable changes in blood markers and initial symptom improvements appear at approximately 2 months, with full stabilization over 2 years. Approximately 90% of patients treated under the Coimbra Protocol achieved a normal life over roughly 10 years of clinical use. A case patient showed 85% improvement in depression after one year of silica supplementation under the protocol. The Coimbra Protocol doses vitamin D3 at 1,000 IU per kilogram of body weight per day. Emergency loading doses of 600,000 IU bypass the 3-month correction delay of standard vitamin D supplementation. The Coimbra Protocol uses therapeutic doses ranging from 40,000 to 200,000 IU/day, calibrated to PTH response rather than blood vitamin D levels. The starting dose formula is 1,000 IU of vitamin D3 per kilogram of body weight per day. The protocol uses parathyroid hormone (PTH) levels as a proxy for vitamin D tissue penetration, increasing the dose until PTH reaches a low-normal level. The Coimbra Protocol uses ultra-high doses of vitamin D3 (50,000–200,000 IU/day) for autoimmune disease management, with documented success across thousands of patients. The protocol uses Vitamin D3 at 10,000 IU per day to calm t…