Collagenase

Topical products containing green coffee bean oil, retinol, and green tea extract can modestly inhibit collagenase at the skin surface but do not stimulate meaningful collagen regrowth in the deeper fascial layer. Collagenase released systemically during the menstrual cycle can degrade the fascial layer in the thighs and buttocks. Collagenase is normally activated during the menstrual cycle to enable monthly shedding of the uterine lining. Repeated monthly collagenase activation degrades fascia faster than the body rebuilds it when mechanical signals to rebuild are absent.