Component Network Meta-Analysis
If the evidence network is too sparse or the additive assumption is not met, CNMA results will be presented as narrative summaries only. Bayesian hierarchical CNMA will be implemented in JAGS with vague priors, with results cross-checked a…
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If the evidence network is too sparse or the additive assumption is not met, CNMA results will be presented as narrative summaries only. Bayesian hierarchical CNMA will be implemented in JAGS with vague priors, with results cross-checked against frequentist implementations. CNMA decomposes complex treatment regimens into pharmacological components (letrozole, clomiphene, gonadotropins) and procedural components (IUI vs timed intercourse) to estimate each element's marginal contribution. Component NMA is the principal methodological novelty of this review, aiming to estimate the marginal contribution of each drug and procedural component to clinical outcomes.