Controlled Human Infection Model
The CHIM uses a standardized controlled exposure that can detect 30% vaccine efficacy with far fewer participants than natural exposure studies. The gonorrhea CHIM was developed at UNC-CH and Walter Reed in the late 1980s and early 1990s.…
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The CHIM uses a standardized controlled exposure that can detect 30% vaccine efficacy with far fewer participants than natural exposure studies. The gonorrhea CHIM was developed at UNC-CH and Walter Reed in the late 1980s and early 1990s. Over 33 years, 257 male volunteers have been challenged without serious or irreversible adverse events. UNC-CH is the only institution currently operating the gonorrhea CHIM platform.