Cross-Protection
N. gonorrhoeae encodes homologues of fHbp, NHBA, GNA2091, and GNA1030, but not NadA. OMV surface proteins from the NmB strain used in 4CMenB share a mean sequence conservation of 91.0% with gonococcal homologues. Human 4CMenB vaccination h…
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N. gonorrhoeae encodes homologues of fHbp, NHBA, GNA2091, and GNA1030, but not NadA. OMV surface proteins from the NmB strain used in 4CMenB share a mean sequence conservation of 91.0% with gonococcal homologues. Human 4CMenB vaccination has demonstrated IgG responses against gonococcal outer-membrane proteins and serum bactericidal activity against N. gonorrhoeae strains. NmB is closely related to N. gonorrhoeae, supporting the plausibility of vaccine cross-protection. The gonococcal fHbp homologue appears intracellular, which may limit its contribution to cross-protection.