Curcumin with Piperine

Piperine may alter medication exposure because it can increase absorption of substances beyond curcumin. Piperine is presented as improving curcumin absorption by inhibiting metabolism and increasing intestinal membrane fluidity. The mechanisms attributed to curcumin include suppression of NF-kB and reduced expression of matrix-degrading enzymes. Curcumin taken alone is described as poorly bioavailable because it is rapidly metabolized and cleared. Curcumin is presented as targeting the inflammatory and matrix-degrading side of joint deterioration.