Cyclic GMP and PDE5
Nitric oxide promotes vasodilation partly through cyclic GMP. PDE5 breaks down cyclic GMP, limiting cyclic GMP-mediated relaxation in vascular and erectile tissue. Hydrogen sulfide is described as potentially preserving cyclic GMP activity…
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Nitric oxide promotes vasodilation partly through cyclic GMP. PDE5 breaks down cyclic GMP, limiting cyclic GMP-mediated relaxation in vascular and erectile tissue. Hydrogen sulfide is described as potentially preserving cyclic GMP activity by acting in a PDE5-inhibiting manner. PDE5 inhibitors such as sildenafil and tadalafil are used for erectile dysfunction because PDE5 breaks down cyclic GMP.