Delirium Prevention Strategies

Pharmacological prevention with antipsychotics has shown weak or inconclusive efficacy and poses significant risks to older patients, including oversedation and cardiac arrhythmias. Non-pharmacological approaches, including reorientation, cognitive stimulation, early mobilisation, and sensory support, represent the current standard of care for delirium prevention. Future delirium prevention trials should enrich enrolment with higher-risk populations and use objective sleep measurement tools such as actigraphy or polysomnography.