Diabetes-Related Cognitive Mechanisms
Chronic hyperglycaemia may damage small vessels and neurons through oxidative stress and advanced glycation end-product formation. Vascular risk factors may impair cerebral perfusion or promote microvascular injury and were more common in…
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Chronic hyperglycaemia may damage small vessels and neurons through oxidative stress and advanced glycation end-product formation. Vascular risk factors may impair cerebral perfusion or promote microvascular injury and were more common in advanced diabetes. Insulin resistance may impair brain insulin signalling and promote amyloid accumulation. The insulin-dependent group’s higher comorbidity burden supported a multifactorial model of diabetes-related cognitive impairment.