Diabetic Complications

Citrus bioflavonoids significantly reduce diabetic vascular complications through the same capillary-permeability protection mechanism. The assumption that a newly diagnosed diabetic has nine more years before complications appear is dangerously wrong due to decades of pre-diagnostic disease progression. Peripheral neuropathy is often among the first complications of diabetes, presenting as tingling, numbness, and burning beginning in the feet and hands. Alzheimer's disease is referred to as Type 3 diabetes due to its connection to insulin resistance and glucose metabolism dysfunction in the brain. Four tissues bear the brunt of diabetic complications: nerves and brain, arteries, eyes, and kidneys. The four most diabetes-damaged tissues share extreme metabolic demand and high oxidative byproduct output, making them uniquely vulnerable. The central problem in diabetes is that excessive glucose generates enormous oxidative stress, with free radicals driving tissue complications. The same vascular mechanism that causes retinopathy also causes peripheral neuropathy, chronic systemic infections, kidney failure, heart disease, and loss of brain function. Only four tissues in the body ar…