Diabetic Gangrene

The fundamental cause of diabetic gangrene is prolonged exposure of vascular tissue to high concentrations of glucose. Gangrene involves a combination of dead tissue, ulcers, and severe nerve damage. Gangrene refers to dead or dying tissue, most commonly beginning in the feet, toes, and sometimes hands. Pain is present in early-stage gangrene, but the area becomes completely numb once the nerve itself dies. Affected tissue can turn black, yellow, red, or greenish in color.