Diagnostic Performance Evaluation
The primary reference standard is a composite clinical standard distinguishing confirmed and unconfirmed TB from unlikely TB using NIH 2015 case definitions. The primary performance metric for CAD evaluation in CAPTURE is AUC, computed usi…
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The primary reference standard is a composite clinical standard distinguishing confirmed and unconfirmed TB from unlikely TB using NIH 2015 case definitions. The primary performance metric for CAD evaluation in CAPTURE is AUC, computed using the R package pROC with 95% confidence intervals from 2,000 stratified bootstrap replicates. Sensitivity and specificity are calculated at two thresholds: the threshold achieving 90% sensitivity, and the manufacturer-recommended threshold. Results will be stratified by age group, sex, HIV status, nutritional status, WHO region, CXR image format, and presence of specific radiological features.