DM199
DM199 therapeutic doses do not lower blood pressure in normotensive individuals according to prior non-pregnant data. The trial uses IV DM199 as a loading dose and SC DM199 for sustained effect over three days. DM199 should not be started…
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DM199 therapeutic doses do not lower blood pressure in normotensive individuals according to prior non-pregnant data. The trial uses IV DM199 as a loading dose and SC DM199 for sustained effect over three days. DM199 should not be started within 24 hours of ACE inhibitor use because ACE inhibition may excessively potentiate bradykinin signalling and cause severe hypotension. DM199 is a purified recombinant formulation of human tissue kallikrein-1 with two stability-related substitutions outside the active site.