Down Syndrome
Down syndrome is the leading cause of genetically defined intellectual disability worldwide. The estimated global incidence of Down syndrome is approximately 1 in 700–800 live births, with 40–50 million people affected worldwide. Hippocamp…
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Down syndrome is the leading cause of genetically defined intellectual disability worldwide. The estimated global incidence of Down syndrome is approximately 1 in 700–800 live births, with 40–50 million people affected worldwide. Hippocampal dysfunction and frontal cortex abnormalities are strongly linked to cognitive impairments in Down syndrome. Cognitive impairment in Down syndrome includes low IQ, planning difficulties, memory impairment, and reduced adaptive behaviour and autonomy. Participants must have free trisomy 21 documented by karyotyping and a mental age between 4.5 and 8.5 years.