Drosophila
Caloric restriction reduced the range of age-related PC1 movement but produced a separate dietary axis not explained by the simple model. The paper reanalyzes Drosophila transcriptome data from aging and caloric restriction experiments. Dr…
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Caloric restriction reduced the range of age-related PC1 movement but produced a separate dietary axis not explained by the simple model. The paper reanalyzes Drosophila transcriptome data from aging and caloric restriction experiments. Drosophila gene-expression profiles shifted away from the youthful state with age along PC1. Radiation-resistance data in Drosophila qualitatively support the model's prediction that lethal dose declines with age in normally aging animals.