Drug Interactions

Estimated prevalence of potentially harmful drug-drug interactions varied greatly by assessment method. Potentially harmful drug-drug interactions were the most common medication-safety outcome in the review. Potentially harmful drug-drug interactions involve clinically meaningful changes in medicine effect or safety due to coadministration with another medicine. The pooled prevalence of potentially harmful drug-drug interactions was 55%. Most respondents felt unable to manage potential drug interactions related to chemsex. For potentially harmful drug-drug interactions, sample size, screening tool, and Hoy risk-of-bias level were significantly associated with prevalence estimates. Some chemsex substances may interact seriously with antiretroviral or psychoactive medicines. Certain medications including warfarin, SSRIs, and statins inhibit the same CYP450 enzymes used to break down other drugs. When multiple drugs share the same CYP450 pathway, one drug can block clearance of another, causing accumulation and intensified side effects. The drug interaction risk is especially concerning for elderly patients who are typically on multiple medications. Age-related low HCl, further acid…