Early Treatment Response
TNF inhibitors are often first biologic choices, but about one-third of patients respond inadequately. A one-month glucocorticoid response serves as a clinical proxy for molecular predictors of conventional DMARD response. A delayed treatm…
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TNF inhibitors are often first biologic choices, but about one-third of patients respond inadequately. A one-month glucocorticoid response serves as a clinical proxy for molecular predictors of conventional DMARD response. A delayed treatment response is associated with erosive disease, functional impairment, and worse long-term quality of life. An inadequate tsDMARD response at month 4 creates an actionable point for switching earlier to a bDMARD.