EBV and HHV-6
IgG, IgM, and IgA antibodies against EBV and HHV-6 dUTPases were elevated in Long COVID patients but not in healthy controls. EBV reactivation by SARS-CoV-2 triggers expression of antigens that cross-react with human tissue, driving autoim…
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IgG, IgM, and IgA antibodies against EBV and HHV-6 dUTPases were elevated in Long COVID patients but not in healthy controls. EBV reactivation by SARS-CoV-2 triggers expression of antigens that cross-react with human tissue, driving autoimmunity. Viral dUTPases released by EBV and HHV-6 activate NF-κB, impair T-cell function, and cross the blood-brain barrier, directly producing neuroinflammation. SARS-CoV-2 peptides cross-react with heat shock proteins HSP60 and HSP90, and anti-HSP autoantibodies are associated with endothelial damage and cardiovascular disorders. HHV-6 reactivation is strongly linked to neuroinflammatory and neuro-autoimmune disorders including Alzheimer's disease, Parkinson's disease, ME/CFS, lupus, and multiple sclerosis.